Whether you’re excited by its possibilities or worried about its potential consequences, large-scale human genome editing appears to be just around the corner thanks to CRISPR – a new gene editing tool unmatched in its revolutionary capabilities and efficiency. So how can we possibly prepare for its ethical implications? In this Parlor Chat, New York Times science journalist Carl Zimmer and Yale University science historian Daniel Kevles discuss how the history of science and regulation might – or might not – be our guide for avoiding social and ethical catastrophe.