From imbalanced humours to brain chemistry – on the evolution of melancholy

The Ancient Greeks blamed sadness on bodily humours called ‘melaina kole’ (black bile). Today, clinical depression is often understood as an imbalance of brain chemicals – although this is a paradigm that many experts believe is overdue for an update. This animation from TED-Ed offers a brief examination of the history of melancholy, scoping how philosophers, poets, writers and scientists have envisioned and altered our understanding of the experience across the ages.