How our bodies can create billions of defences against disease with just 20,000 genes

How is the human body able to produce antibodies to mount a defence against any attacking microorganism – even those it’s never encountered before? After all, our mere 20,000 genes seem woefully inadequate to produce the billions of different antibodies necessary to fight every possible disease. The problem stumped researchers for decades until the Japanese scientist Susumu Tonegawa discovered the key to our incredible adaptive capacity for fighting contagions – an accomplishment that earned him the Nobel Prize in Physiology or Medicine in 1987. The answer, explored in this brief animation from Nature, lies in recombination-activating genes (RAGs) – DNA-‘shuffling’ enzymes that can create proteins capable of fighting any foreign invader.

‘It makes sense of everything I am.’ The transcendence of the long-distance swimmer

but today you swirl and spin
in sea water as if,
creatures of salt and slime
and naked under the sun,
life were a waking dream
and this the only life.
– From ‘A Swim in Co Wicklow’ (2011) by Derek Mahon

In 2012, the Irish long-distance swimmer Stephen Redmond became the first person to complete the Ocean’s Seven challenge, which includes marathon swims in seven channels around the world. In The Swimmer, the Irish filmmaker Thomas Beug takes us along on a brisk Atlantic swim, gracefully weaving lyrical images of Redmond on land and in the water with his musings on the ineffable sense of purpose he finds in the open water. Complementing Redmond’s narration are lines written and performed by the Irish poet Derek Mahon, offering a refreshing glimpse of the sublime and the spiritual within the realm of extreme sports.

How the philosophical paradox of aspiration is resolved by a new theory of self-creation

Let’s say you’ve decided to enrich yourself by learning to appreciate classical music, even though you didn’t have much previous interest in it. Such a resolution is hardly uncommon, but acting on the aspiration requires you to value an activity that you don’t yet know how to. In this video, Agnes Callard, associate professor of philosophy at the University of Chicago, borrows from her book Aspiration: The Agency of Becoming (2018) to put forth a solution to this paradox centred on understanding our current and future selves as inexorably bound through the act of aspiration. Further, she argues, in resolving this paradox, we can understand ourselves as responsible for the act of self-creation – and, by extension, for our own morals and values. This video is part of the series Into the Coast, which sets out to capture philosophy as a ‘living discipline’ through interviews with leading academic philosophers.

The violinist staging a concert of unity at the border between North and South Korea

The South Korean violinist Hyung Joon Won has held a singular – and perhaps quixotic – dream for the past seven years: a joint concert by North and South Korean musicians at the world’s most contentious border. At 160 miles long and 2.5 miles wide, the Korean Demilitarised Zone (DMZ) separates the two countries at the 38th parallel. On this narrow strip, the threat of all-out war hangs heavy – and anyone with a violin case or a film camera gets short shrift. The South Korean-born filmmaker Catherine Kyungeun Lee follows Hyung Joon as his plan for a show of peace at the border teeters between success and collapse, at great personal cost to him. Filmed in 2015, her documentary traces the confluence between fraught geopolitics and all-too-human struggles on the peninsula.

Lee is now directing two documentaries in East Africa. One tells the story of a child-soldier who became a Harvard graduate and activist who was jailed in South Sudan, and the other follows the woman in charge of realising Somalia’s first democratic election in 50 years, despite seemingly insurmountable opposition.

Basic healthcare and clean needles is all in a day’s work at a roving addiction clinic

Marc Lasher works as an addiction medicine specialist but, between his regular appointments, he oversees a clean-needle exchange on the streets of Fresno County in California, out the back of a modified school bus. Lasher’s decades-long dedication to public health is all the more impressive considering that his programme was illegal in the state until 2012. In the wake of the opioid epidemic, his approach – addressing drug addiction as a matter of public health rather than criminality – has only recently come into favour in much of the United States. In this acclaimed documentary, the US filmmaker Elivia Shaw follows Lasher and a team of young volunteers as they provide people coping with addiction with clean needles, as well as basic medical care and referrals to specialists and detox centres. The result is both a moving testament to Lasher and his team’s selfless work and a damning indictment of a healthcare system in which unaddressed health issues, costs and the physical and emotional tolls of poverty compound each other relentlessly.