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Immunology wars: a billion antibodies

3 minutes

This adorable sea slug is a sneaky little thief

4 minutes

The human voice

3 minutes

Mobilize

4 minutes

Frames of reference

27 minutes

How our bodies can create billions of defences against disease with just 20,000 genes

How is the human body able to produce antibodies to mount a defence against any attacking microorganism – even those it’s never encountered before? After all, our mere 20,000 genes seem woefully inadequate to produce the billions of different antibodies necessary to fight every possible disease. The problem stumped researchers for decades until the Japanese scientist Susumu Tonegawa discovered the key to our incredible adaptive capacity for fighting contagions – an accomplishment that earned him the Nobel Prize in Physiology or Medicine in 1987. The answer, explored in this brief animation from Nature, lies in recombination-activating genes (RAGs) – DNA-‘shuffling’ enzymes that can create proteins capable of fighting any foreign invader.

Video by Nature

Animator: Dog & Rabbit

How our bodies can create billions of defences against disease with just 20,000 genes

How is the human body able to produce antibodies to mount a defence against any attacking microorganism – even those it’s never encountered before? After all, our mere 20,000 genes seem woefully inadequate to produce the billions of different antibodies necessary to fight every possible disease. The problem stumped researchers for decades until the Japanese scientist Susumu Tonegawa discovered the key to our incredible adaptive capacity for fighting contagions – an accomplishment that earned him the Nobel Prize in Physiology or Medicine in 1987. The answer, explored in this brief animation from Nature, lies in recombination-activating genes (RAGs) – DNA-‘shuffling’ enzymes that can create proteins capable of fighting any foreign invader.

Video by Nature

Animator: Dog & Rabbit

Far from sluggish: the remarkable sea creature that weaponises its dinner

Nudibranchs, also commonly known as sea slugs, are a group of snail-like sea invertebrates. Despite appearing more or less defenceless, nudibranchs broadcast their whereabouts with their flamboyant, brightly coloured bodies. From an evolutionary standpoint, it might seem like a curious move, but their luminous skin actually serves as a warning to would-be predators to let them know they’d make for a dangerous meal. While some nudibranchs accumulate toxins and other defensive chemicals in their bodies, others – like the star of this film – have an even craftier method of warding off enemies. This remarkable short from the science and nature documentary series Deep Look details the clever way that some nudibranchs protect themselves by stealing defences from stinging sea animals known as hydroids. You can read more about this video at KQED Science.

Video by KQED Science

Producer and Writer: Josh Cassidy

Narrator and Writer: Lauren Sommer

‘My God! Where’s the human voice?’ A charming reflection on our pre-recorded world

From to Siri to subways to customer service calls, pre-recorded and robotic voices are becoming an increasingly inescapable part of the human experience. In this short animation from StoryCorps, the US author, historian and broadcaster Studs Terkel (1912–2008) reflects on this trend away from human interaction and toward disembodied sentence fragments. Recalling a scene from a tram ride at Atlanta airport with exceeding wit and charm, he considers the richness of the human voice, and what we lose when it’s replaced.

Director: The Rauch Brothers

Producer: Lizzie Jacobs

From canoes to cities, a frenetic celebration of the power of indigenous Canadians

In her short film Mobilize, Caroline Monnet – a Canadian filmmaker and artist of French and Algonquin origin – uses archival documentary footage to honour the restless diligence of Canada’s indigenous people. Given access to more than 700 films from the National Film Board of Canada for the project, Monnet crafts a fervent visual collage that spans the country’s rural north, where indigenous craftsmen are seen fashioning canoes, to scenes from skyscraper construction in the urban south. According to Monnet, in making the film, she sought to explore the trajectory of her own family’s history, as well as to simply bombard viewers with ‘images of indigenous people kicking ass on screen’. Heightened by a feverish score from the Inuk artist Tanya Tagaq, Monnet’s film offers a deeply original and personal perspective on the indigenous Canadian experience.

Director: Caroline Monnet

Score: Tanya Tagaq

Producer: Anita Lee

Website: National Film Board of Canada

This clever and stylish 1960 film is the most fun you’ll ever have at a physics lecture

Directed by the pioneering UK documentarian Richard Leacock, Frames of Reference is a slick and surreal dive into physics fundamentals and, in particular, why everything is indeed relative. Produced for high-school physics classes, the 1960 film features the physics professors Patterson Hume and Donald Ivey of the University of Toronto explaining, through an intertwined series of lectures and clever demonstrations, how frames of reference shape perspective. Using rotating sets, camera tricks and a visual style that suggests the film noir of Alfred Hitchcock, this is perhaps the most peculiarly entertaining half-hour physics lecture you’ll ever have.

Director: Richard Leacock

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