How our bodies can create billions of defences against disease with just 20,000 genes

How is the human body able to produce antibodies to mount a defence against any attacking microorganism – even those it’s never encountered before? After all, our mere 20,000 genes seem woefully inadequate to produce the billions of different antibodies necessary to fight every possible disease. The problem stumped researchers for decades until the Japanese scientist Susumu Tonegawa discovered the key to our incredible adaptive capacity for fighting contagions – an accomplishment that earned him the Nobel Prize in Physiology or Medicine in 1987. The answer, explored in this brief animation from Nature, lies in recombination-activating genes (RAGs) – DNA-‘shuffling’ enzymes that can create proteins capable of fighting any foreign invader.

If you think that modern cosmology leaves no room for ‘god’, start using your imagination

‘We’re not so much abandoning the idea of the gods, we’re just trying to pull them all the way into the Universe.’

From the possibility of infinite universes to the prospect of panpsychism, puzzles have arisen in physics that can take science to some very counterintuitive places. According to Mary-Jane Rubenstein, assistant professor of religion and feminist, gender and sexuality studies at Wesleyan University in Connecticut, new theories and breakthroughs at the forefront of cosmology need not – and moreover, should not – elbow out theology from the conversation about our place in the cosmos. Instead, as she argues in this wide-ranging interview recorded at the HowTheLightGetsIn Festival from the Institute of Arts and Ideas in 2019, science should encourage us to build more durable myths and theologies to suit our times.

What is it to be Bayesian? The (pretty simple) math modelling behind a Big Data buzzword

If you’ve ever tripped up over the term ‘Bayesian’ while reading up on data or tech, fear not. Strip away the jargon and notation, and even the mathematics-averse can make sense of the simple yet revolutionary concept at the core of both machine learning and behavioural economics. As this video from the YouTube channel 3Blue1Brown skilfully explains, at its most basic, Bayes’s theorem is a tool for assessing degrees of probability based on prior conditions. And there are ways to make it altogether more intuitive than the statistical formulas might suggest. Although the theorem dates back to its 18th-century namesake, the English statistician and philosopher Thomas Bayes, it has gained increasing relevance in the Big Data revolution.

‘They told us to stay put’: the South Korean ferry disaster that sank lives and trust

On 16 April 2014, the ferry MV Sewol sunk off the coast of South Korea, killing 304 people – the vast majority of them high-school students on a field trip. Like many other tragedies, the event made headlines around the world before quickly fading from the international news cycle. In South Korea, however, facts about the incompetence, government failures and lapses in responsibility that led to the Sewol’s sinking emerged slowly over the course of several years, prolonging pain and stoking anger to the present day. The documentary In the Absence by the South Korean director Yi Seung-Jun is a devastating account of the sinking and its aftermath – from the first signs of trouble at sea to the years-long struggle by bereaved families demanding accountability and justice. Combining original material with real-time audio and video of the tragedy, the film offers an extraordinary, chilling account of the consequences of following instructions from inept authorities – and the profound breakdown of public trust that follows such a disaster.

Dadaism ridiculed the meaninglessness of modern life – with captivating results

Dadaism was an avant-garde artistic movement born amid the wreckage of the First World War in Europe and formed in reaction to the perceived meaninglessness of modern life – in particular, of capitalism and its violence. The Swedish artist Viking Eggeling’s stop-motion animation Symphonie diagonale is considered both a Dadaist masterpiece and an early example of experimental animation. Basing the imagery on drawings he created alongside the influential German artist and fellow Dadaist Hans Richter, Eggeling revised and screened several versions of the short from 1922 up until his death in 1925. Shown as a silent film upon its release, this version of Symphonie diagonale features an original score, exclusive to Aeon. The contemporary Illinois-based composer William Pearson intends his music to react to Eggeling’s original vision in both style and composition, with playful, occasionally mechanical organ sounds, and melodies forming in sequence with the visuals emerging on screen.