Are the mysteries of reality within the grasp of science? Or does a strictly empirical, Western materialist approach fail to properly consider the role of humans as observers? In this video from the Institute for Cross-Disciplinary Engagement at Dartmouth (ICE), the US theoretical physicist Sean Carrol argues that, through scientific enquiry, a comprehensive understanding of reality is within our reach. Indeed, one layer of our reality – the world of elementary particles and forces – has already been entirely accounted for. Countering him, the US scholar of Tibetan Buddhism B Alan Wallace argues that such a materialist account of our Universe fails to fully account for both the complexities of the human mind and the world outside it.